The museum contains finds from the district of Aetoloacarnania, ranging from the Prehistoric to the Roman periods.

The most important items of the exhibition are:

Mycenaean one-handled squat jug decorated with cross-hatched loops and flowers

Marble acroterion. Corner acroterion from the Heroon of Alyzia, dated to the 2nd century A.D.

Protome of Herakles from the Heroon of Calydon.

Protome of Eros from the Heroon of Calydon.

Protome of Aphrodite "armata" from the Heroon of Calydon.

Head of Zeus from the Heroon of Calydon.

Protome of Meleagros from the Heroon of Calydon.

Stone door from the burial chamber of the Heroon of Calydon.

Painted clay sima bearing representations of Victories (Nikae) on chariots. From the Laphrion at Calydon.

Roof tile. Front surface of a cover-tile in the shape of a female head, from the Laphrion at Calydon.